| 29 NOVEMBER 2023 WEDNESDAY – B CONFERENCE HALL, BESIKTAS, ISTANBUL | ||
| 08:00-09:30 | Registration | |
| 09:30-10:00 | Opening Ceremony | |
| 10:00-10:30 | BÜLENT ÖZPOLAT | Development of microRNA-based therapeutics for Targeted Cancer Therapy |
| 10:30-11:00 | COFFEE BREAK | |
| SESSION-I Chair: BÜLENT ÖZPOLAT, CANAN ATILGAN |
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| 11:00-11:30 | THOMAS MAVROMOUSTAKOS | Discovery of Old and New Drugs |
| 11:30-11:45 | NİLAY ÇOLAK | Development and Optimization of a Novel “Chimeric Protein Reporter” Screening Assay for TGFβ-SMAD Signaling |
| 11:45-12:00 | BÜŞRA TAYHAN | The Effect of Conformational Dynamics on Calmodulin-Mediated Sensor Activity |
| 12:00-12:15 | İSMAİL EROL | Does carvedilol block hERG via an extracellular pathway? |
| 12:15-12:30 | LALEHAN OKTAY | Neural Relational Inference Models for Optimized Virtual Screening of Large-Scale Small Molecule Libraries using Dynamic Structure-based Pharmacophore Models for the Treatment of YB-1 Mediated Drug Resistance |
| 12:30–13:30 | LUNCH | |
| SESSION-II Chair: THOMAS MAVROMOUSTAKOS, İSMAİL EROL |
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| 13:30-14:00 | CANAN ATILGAN | Making Sense of Antibiotic Resistance in the TolC Efflux Pump |
| 14:00-14:30 | HASAN DEMİRCİ | 3D&4D SFX Driven Designer Therapeutics Development at Ambient Temperature |
| 14:30-15:00 | TUĞBA BAĞCI ÖNDER | Epigenetic Targeting of Glioblastoma |
| 15:00-15:10 | IOANNIS PAPAZOGLOU | Targeting AT1R with RNA aptamers to manage Retinal Degeneration |
| 15:10-15:20 | SAIDA ASHRAF | Unraveling Potential: Tailoring Liver Pyruvate Kinase Inhibitors via Structural Guided Optimization |
| 15:20-15:30 | SHAZIA IQBAL | Discovery of Small Molecules as Potential Therapeutics for NAFLD and HCC |
| 15:30-16:00 | COFFEE BREAK | |
| SESSION-III Chair: HASAN DEMİRCİ, TUĞBA BAĞCI ÖNDER |
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| 16:00-16:30 | SERKAN KIR | EDA2R-NIK Signaling Promotes Muscle Atrophy Linked to Cancer Cachexia |
| 16:30-17:00 | MERT GÜR | Exploring the Priming Stroke of Dynein-2 Linker Through Millisecond-Long Molecular Dynamics Simulations |
| 17:00-17:10 | SÜMEYRA AYAN | Synthesis, Purification and Characterization of Spike-Angiotensin Converting Enzyme-2 Targeted Drug Candidate Peptides against SARS-COV-2 |
| 17:10-17:20 | KÜBRA ARANCI ÇİFTÇİ | Synthesis and Characterization of Peptide Molecules Targeting TMPRSS2 for COVID-19 Drug Studies |
| 17:20-17:30 | YAĞMUR YEŞİLYURT | Investigation of the Effect of Dioncophyllin A on DNA through Molecular Dynamics Simulation |
| 17:30-17:40 | PINAR SİYAH | Unveiling New Therapeutic Avenues: Targeting Cancer via Focal Adhesion Kinase Inhibition |
| 17:40-17:50 | YUSUF ŞİMŞEK | In Silico Identification of Sclerostin Inhibitors |
| 17:50-18:00 | ZÜLAL KESMEN | De Novo Antimicrobial Peptide Design Against Drug-Resistant Staphylococcus Aureus |
| 30 NOVEMBER 2023, THURSDAY – B CONFERENCE HALL, BESIKTAS, ISTANBUL | ||
| SESSION-IV Chairs: PHIL BIGGIN, MUSTAFA GUZEL |
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| 09:15-09:45 | PETER KOLB | Ligand Discovery for GPCRs: New Molecules, Sites & Ways of Modulation |
| 09:45-10:15 | VİKTORYA AVİYENTE | Quantum-Mechanical Prediction Of The Dissociation Constants For Drug-Like Molecules |
| 10:15-10:45 | ÖZLEM KESKİN | Protein-protein interfaces: Drug Repurposing in Ras/Raf/MEK/ERK Signaling Pathway |
| 10:45-11:15 | COFFEE BREAK | |
| SESSION-V Chairs: OZLEM KESKIN, VIKTORYA AVIYENTE |
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| 11:15-11:45 | PHIL BIGGIN | MEMENTO: Why it is Useful to be Forgetful in Conformational Sampling (especially Transporters) |
| 11:45-12:15 | ABDULKADİR KOÇAK | Revisiting MMPBSA by Adoption of MC-Based Surface Area/Volume, ANI-ML Potentials, and Two-Valued Interior Dielectric Constant |
| 12:15-12:45 | ENGİN ULUKAYA | Critical Considerations on Preclinical Evaluation of Newly Synthesized Anticancer Compounds |
| 12:45-13:30 | LUNCH | |
| SESSION VI Chairs: ENGIN ULUKAYA, ABDULKADIR KOCAK |
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| 13:30-14:00 | NUR MUSTAFAOĞLU | Physiologically relevant human cell-based blood-brain barrier models |
| 14:00-14:30 | SEDA ÜNSALAN | The Requirements for Bioequivalence Studies of Immediate Release Formulation |
| 14:30-14:50 | SERDAR DURDAĞI | Mol2Drug: Development and Pretesting of a Deep Learning Based Mobile Application on Prediction of Biological Activity and Toxicity of a Molecule from Provided Image “mol2drug.com” |
| 14:50-15:05 | ELİF EREN | Pore-Forming Proteins that Trigger Necrotic Cell Death as New Druggable Targets |
| 15:05-15:20 | FATAY CHERIFI | In silico and in vivo outcomes on Cerastokunitz: A twofold potential therapeutic biopeptide with valuable pharmacological anti-thrombosis and anti-tumoral activities |
| 15:20-16:00 | COFFEE BREAK | |
| SESSION VII Chairs: SEDA UNSALAN, PINAR SIYAH |
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| 16:00-16:30 | İSMAİL TUNCER DEĞİM | Pharmaceutical Drug Design through Formulation Evolution for Nanocomposites: Nanobang |
| 16:30-16:50 | KAYA BİLGUVAR | Common diseases, rare variants, unique patients: towards individualized treatments |
| 16:50-17:20 | ALİ MAXIMILIAN ERTÜRK | Decoding Diseases in 3D: AI-Powered Cell Level Imaging and OMICS |
| 17:20-17:30 | DİLEK KUZALIÇ BURUCU | Manganese (Mn) doped Fullerenes as a MR imaging material for anticancer drug-Thiotepa: A DFT Study |
| 17:30-17:40 | KHAWAJA FAHEEM SHAHID | In Silico Assessment of Nigella Sativa Phytochemicals Targeting Key Proteins in Aspergillus fumigatus |
| 17:40-17:50 | EDANUR DÜZGÜN | Targeting EGFR in Lung Cancer: Novel Inhibitors and Molecular Insights with X-ray Crystallography |
| 17:50-18:00 | NEVİN BELDER | INHBA is a potential biomarker and therapeutic target for patients with colorectal cancer |
| 18:00-18:10 | AYNURA MAMMADOVA | The effect of MEIS Inhibition in Cardiac Regeneration and Protection |
| 18:10-18:20 | MELİKE CANPOLAT | A Novel De Novo Design Approach For Proline-Rich Antimicrobial Peptide Pr26 |
| 18:20-19:20 | POSTER PRESENTATIONS-I (Presentation List) | |
| 01 DECEMBER 2023, FRIDAY – B CONFERENCE HALL, BESIKTAS, ISTANBUL | ||
| SESSION VIII Chairs: BERT DE GROOT, EMRAH EROGLU |
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| 09:15-09:45 | ERDEN BANOĞLU | Targeting Cancer Cells by Inhibition of Transforming Acidic Coiled-Coil Protein 3 (Tacc3): A Novel Therapeutic Strategy For The Treatment of Various Cancers |
| 09:45-10:15 | AMIRHOUSHANG BAHRAMI | Cellular Uptake of Nano Drug Containers With Different Shapes And Sizes |
| 10:15-10:40 | TAMER ÖNDER | Chemical Biology Approaches to Generating Induced Pluripotent Stem Cells |
| 10:40-11:15 | Coffee Break | |
| Session IX Chairs: Tamer Onder, Erden Banoglu |
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| 11:15-11:45 | BERT DE GROOT | Alchemical Binding Free Energy Calculations And Machine Learning Based Chemical Space Navigation |
| 11:45-12:15 | EMRAH EROGLU | Cellular Symphony: Decoding Drug Actions Using Genetically Encoded Biosensors |
| 12:15-12:40 | GÖZDE KORKMAZ | Precision Medicine in Breast Cancer: Harnessing Synthetic Lethality and ERalpha Detection |
| 12:40-13:30 | Lunch | |
| Session X Chairs: Amirhoushang Bahrami, Gozde Korkmaz |
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| 13:30-14:00 | ADİL MARDINOĞLU | The use of Systems Biology in Drug Development |
| 14:00-14:30 | NURHAN ÖZLÜ | Role of Palmitoylation in Cell Division |
| 14:30-15:00 | EMEL TİMUÇİN | Completion Of The Aurora Interaction Region Of N-Myc In The Aurora A Kinase Complex |
| 15:00-15:30 | MUSTAFA GÜZEL | Discovery of a Molecule with Potential in Cancer Treatment |
| 15:30-16:30 | Coffee Break | |
| Session XI Chairs: Emel Timucin, Mustafa Guzel |
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| 16:30-17:00 | TUNCA DOĞAN | AI-Driven Prediction Of Molecular And Drug-Related Properties Via Chemical Language Models |
| 17:00-17:10 | YEKBUN ADIGÜZEL | Possible Molecular Mimicry-Based Autoimmunity Mechanism Studied Through Hla-Affinity Changes At Omicron(21K,21L) Mutation-Regions |
| 17:10-17:20 | ASAF EVRIM EVREN | Design And Synthesis Novel Oxadiazole-Thiadiazol As Aromatase Inhibitors: In Vitro And In Silico Evaluation |
| 17:20-17:30 | EHSAN SAYYAH | Developing Dynamic Structure-Based Pharmacophore and QSAR Models for the Discovery of Novel Resistance-Free RET Tyrosine Kinase Inhibitors through Long Molecular Dynamics Trajectories for Accelerated Ligand Screening |
| 17:30-17:40 | FİLİZ YARIMCAN | New Drug Discovery Approaches For Antibiotics In The Era Of Increasing Rate Of Panresistant Bacterial Isolates |
| 17:40-17:50 | ZAINAB ALI MOHAMUD SABRIE | Protective Effect Of Selective Mtorc2 Inhibition On Zymosan-Induced Hypotension In A Rat Model Of Non-Septic Shock: Contribution Of Ikkα/IΚB-Α/NF-ΚB Pathway |
| 17:50-18:00 | BURCU BAKIR-GÜNGÖR | Match Score Motif Representation To Design Novel Antimicrobial Peptides |
| 18:00-18:10 | MAHA MORAL | Synthesis And Functionalization Of Nanosized Metal-Organic Framework (Mof) For Targeted Controlled Release Cancer Therapy |
| 18:15-19:15 | POSTER PRESENTATIONS-II (Presentation List) | |
| 02 DECEMBER 2023, SATURDAY – B CONFERENCE HALL, BESIKTAS, ISTANBUL | ||
| SESSION XII Chairs: MİNE İSAOĞLU, LALEHAN OKTAY |
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| 09:30-10:00 | KADIRCAN KESKİNBORA | Pharmaceutical System and Ethics |
| 10:00-10:30 | ŞARON ÇATAK | Impact of Deamidation on Bcl-xL structure and function |
| 10:30-10:45 | MURAT SERİLMEZ | Computational approaches and potential drug candidates for anticancer drug discovery RAB-GTAPases |
| 10:45-11:15 | COFFEE BREAK | |
| SESSION XIII Chairs: SARON CATAK, KADIRCAN KESKINBORA |
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| 11:15-11:45 | ÇAĞATAY AYDIN | Unraveling drug-related electrophysiological footprints using high-density neuronal probes |
| 11:45-11:55 | MİNE İSAOĞLU | Discovery of Novel Potential Non-Nucleoside DNA Methyltransferase Inhibitors as Potential Anti-Cancer Therapeutics through Integrated Virtual Screening Algorithms |
| 11:55-12:05 | MUHAMMAD TAHIR UL QAMAR | Machine Learning for Synergistic Network Pharmacology |
| 12:05-12:15 | SEMA ŞENOĞLU | Synthesis, Characterization, and Molecular Docking Studies of Novel 1,3-thiazoline Derivatives |
| 12:15-12:25 | TOSIN FAJEMBOLA | Evaluation of the pharmaceutical potential of components of aniseed and flaxseed against Shigellosis through in silicio and in vitro analysis |
| 12:30-13:30 | LUNCH | |
| SESSION XIV Chairs: ISMAIL EROL, LALEHAN OKTAY |
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| 13:30-14:00 | ONUR SERÇİNOĞLU | Exploring Autoimmune Disease Mechanisms: A Structural Bioinformatics View of MHC Class I Diversity |
| 14:00-14:10 | SAIMA IKRAM | Decoding Small-Molecule Modulation of OX40–OX40L Interaction and its Immunomodulatory Significance |
| 14:10-14:20 | OUSSAMA ABCHIR | Virtual Screening Of A Large Set Of Compounds As Candidate Drugs Against Alpha Amylase-Activity, ADMET, And Molecular Dynamics Simulation |
| 14:20-14:30 | EZGİ KESKİN TALDARI | In Silico Analysis Of Phytochemicals For Use In COVID-19 Treatment And Assessment Of Binding Properties Of Potential Drug Candidates |
| 14:30-14:40 | SERAP MERT | Investigation Of Emulsification Formulations Of Pemetrexed Loaded Polymeric Nanoparticles |
| 14:40-14:50 | AYCAN SEZAN | In Silico And In Vitro Analysis Of The Interaction Of Thymoquinone Among Some Oncogenic Driver Proteins |
| 14:50-15:00 | Müge Didem ORHAN | Investigation Of Cells And Cytokines Involved In Demyelination And Remyelination Process Via The Multiple Sclerosis Cuprizone Model Using Hematopoietic Stem Cell Transplantation |
| 15:00-15:30 | COFFEE BREAK | |
| SESSION XV Chairs: SAIMA IKRAM, SALMA GHAZY |
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| 15:30-16:00 | AHMET GÜL | Development of nanobodies for inflammasomopathies |
| 16:00-16:30 | ELIF NUR FIRAT KARALAR | Deciphering The Molecular Underpinnings Of Ciliopathies |
| 16:30-16:40 | SALMA GHAZY | An Innovative Algorithm for the Virtual Screening of Exceptionally Vast Libraries of Small Molecules Against ERCC1-XPF Binding Pockets with the aim of Identifying Small Anti-Cancer Compounds Devoid of Therapeutic Resistance |
| 16:40-16:50 | YAMARI IMANE | Virtual Screening, Molecular Dynamics, And In-Silico Adme-Tox Analysis Of Natural Compounds For Exploration Of Potential Antifungal |
| 16:50-17:00 | OKAN SEZGİN | Identifying small molecule protein-protein interaction inhibitors as resistance-free anti-cancer therapeutics targeting c-MET/HGF interface using an innovative hybrid virtual screening algorithm |
| 17:00-17:10 | Asal Ghaffari Zaki | A novel approach for precise manipulation of intracellular pH |
| 17:10-17:30 | CLOSING CEREMONY AND POSTER AWARDS | |